Metallomics is a multidisciplinary science that merges chemistry, biology, physics, and medicine to explore the functions of metal ions in biological contexts. It explores the function of the metallome, which encompasses the entire range of metals present within organisms. Utilizing sophisticated techniques, it investigates the concentrations, distributions, and interactions of these metals within biological cells, tissues, and organs.
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The Metallome Connects "The Omes"
Led by Oxford Academic, the healthcare industry has started to increasingly recognized the importance of the metallome — the comprehensive study of metal ions within biological systems — beyond just diagnostics and further into advancing cellular nutrition, medical research, and therapeutic treatment.
The metallome is intricately connected to other "omes" such as the genome, proteome, microbiome, and more, influencing and being influenced by those biological systems through its role in essential metal ion regulation and interactions.
The metallome is critical for a myriad of biological processes, including the synthesis of proteins, maintaining charge balance and electrolyte function, ensuring DNA integrity and facilitating DNA repair, as well as playing a key role in the structure, signaling, and stem cell functionality.
We lead the isotopic fractionation research in the field metallomcs by studying the isotopic signatures of essential elements. Understanding the interactions of isotopic ratios and their physiological dynamics is essential for deciphering their imbalances, often linked to chronic inflammation and oxidative stress, and for probing the basic mechanisms underlying vital life processes.
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The Vanguard in The Isotope-Selective Modulation
Treating life-threatening neurodegenerative diseases and devastating neurological disorders are one of the biggest challenges of modern medicine. While the treatments are very few, there is no cure for most diseases, and their etiology is unknown. This challenge gives our team the biggest opportunity to help over a billion people to have a better and longer life.
We are pioneering the field of Metallomics for over a decade, offering a unique and proprietary scientific approach to understanding disease origins. Our research goes beyond molecular patterns to examine isotopic signatures at the atomic level in cells and tissues, contributing to the study of metalloproteomics.
Unhealthy aging, concurrent with exposure to dietary and environmental factors hazards, can exacerbate the isotopic fractionation in biological cells, which becomes a driving force in a progress of pathology.
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