We investigate the concentrations, distributions, and interactions of various stable isotopes within molecules, organelles, cells, and tissues. We believe that isotopic ratios are essential for deciphering the etiology of diseases and designing the mechanisms leading to restoring healthy cellular functions.
Precision Drug Delivery
The medical use of stable isotopes in various small molecules is pivotal for their ability to cross the blood-brain barrier, enabling direct engagement with metalloproteins and cellular processes. The inherent safety profile of stable isotopes in metallome highlights its transformative potential in the development of novel pharmaceuticals, hence, promising new era of treatments that are both more effective and clinically safe.
Utilizing sophisticated mass spectrometry techniques, we investigate the isotopic concentrations, distributions, and interactions of essential metals in protein folding, DNA repair, mitochondrial function, apoptosis, and other biological processes. Disruption of these functions are often linked to harmful protein aggregation, chronic inflammation and oxidative stress, and cellular death.
Understanding the isotopic effects in these processes will help to elucidate the basic mechanisms underlying vital life processes and to design inherently-safe and effective therapies capable to restore vital cellular and organ functions.
Our goal is to become the world's leading metallomics pharma company developing inherently safe, effective, and clinically de-risked, disease modifying drugs for treatment of complex diseases.
