Dr. Sergei Petukhov, DVM
Co-Founder & CEO
We are out-of-the box thinkers charged with the mission to bring truly novel medicines forward through understanding isotopic dysfractionation and developing safe, effective, and clinically derisked small molecular isotopic modulators.
Metals and isotopic fractionation play broad roles in human physiology, and we are currently focused on those roles in tumors, as well as in inflammation and oxidative stress. These are closely interrelated processes that lead to cellular dysfunctions and disease progression. By selectively modulating cellular isotopic signatures with non-radioactive isotopes, we aim to restore the healthy interplay between cellular homeostasis, inflammatory and oxidative response, and to offer new effective treatments for oncological, neurodegenerative, and other diseases of aging.
Current Focus on 64Zn Isotope
Targeting isotopic dysfractionation of zinc via multiple pathways without suppressing the immune system
Oncology
Ongoing Phase 1/2 Clinical Trials in malignant neoplasms and CLL
Metabolic
Preparing for Phase 1 clinical trial in Type 2 Diabetes and NAFLD
Neurology
Preparing for Phase 1 clinical trials in PD, LBD, and AD
Autoimmune
Designing animal studies for MS and Hashimoto disease
ISM Drug Development Platform
ISM Drug Development Platform
Our expertise is centered around the integration of Metallomics and pharmaceutical development, focusing on the role and function of isotopic fractionation and roles of stable isotopes within metalloproteomics. Unlike conventional medications that typically interact with their targets on a surface level, thereby managing symptoms rather than the root cause, our isotope-selective modulation, in conjunction with a multi-omic approach, empowers us to create drugs that holistically influence critical biological processes, ranging from protein synthesis and DNA repair to mitochondrial function, and reduction of local any systemic inflammation and oxidative stress.
Making The Difference
Inflammation and oxidative stress play important roles in the development of several chronic conditions affecting many organs. These conditions are interconnected and intensify one another, thus fueling a "snowball" effect that accelerates the progression of many dysfunctions leading to life-threatening diseases.
Metallome deficiencies in general, and isotopic fractionation in particular, may induce chronic pro-inflammatory state and oxidative stress, also impairing protein folding and stability, mitochondrial and lysosomal functions, and other vital processes, which offers new and unique way for modern science to perceive degeneration and ageing.
Isotopically enriched zinc-64 plays a critical role in reducing inflammation and oxidative stress via several mechanisms of action, which renders a therapeutic effect on many vital organs.
Isotopically enriched zinc-64 plays a critical role in reducing inflammation and oxidative stress via several mechanisms of action, which renders a therapeutic effect on many vital organs.
